Hippocampal spine changes across the sleep–wake cycle: corticosterone and kinases

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Hippocampal spine changes across the sleep-wake cycle: corticosterone and kinases.

The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive to CORT, since glucocorticoid receptors are highly expressed. In rat hippocampus fixed in a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased upon waking (within 3 h), as compared with the spine density in the sleep state. Particularly, the large-head s...

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ژورنال

عنوان ژورنال: Journal of Endocrinology

سال: 2015

ISSN: 0022-0795,1479-6805

DOI: 10.1530/joe-15-0078